TY - JOUR T1 - Feasibility and Characteristics of Pressurized Aerosol Chemotherapy (PAC) in the Bladder as a Therapeutical Option in Early-stage Urinary Bladder Cancer JF - In Vivo JO - In Vivo SP - 1369 LP - 1372 DO - 10.21873/invivo.11388 VL - 32 IS - 6 AU - AGATA MIKOLAJCZYK AU - VERIA KHOSRAWIPOUR AU - JUSTYNA SCHUBERT AU - MICHAL PLOCIENNIK AU - KACPER NOWAK AU - CHRISTIAN FAHR AU - HARIS CHAUDHRY AU - TANJA KHOSRAWIPOUR Y1 - 2018/11/01 UR - http://iv.iiarjournals.org/content/32/6/1369.abstract N2 - Background: Pressurized aerosol chemotherapy (PAC) is a novel approach to the treatment of surface malignancies. This study aimed to investigate whether PAC is a feasible treatment of early-stage bladder cancer. Materials and Methods: PAC via inserted microcatheter was performed on a fresh urinary bladder in a post-mortem swine model (n=3), creating a pressurized doxorubicin chemoaerosol. Drug penetration of aerosolized doxorubicin at different concentrations (3 mg/50 ml, 9 mg/50 ml and 15 mg/50 ml) and different locations on the mucosa was measured via fluorescence microscopy. Results: Mean endoluminal penetration rates for the urothelium following PAC reached 149±61 μm (using 15 mg/50 ml). Doxorubicin penetration was significantly increased with higher drug concentration (15 vs. 3 mg/50 ml: p<0.01). This study demonstrated the feasibility of PAC for intravesical use. Conclusion: PAC is a feasible minimally-invasive approach to the treatment of early-stage bladder cancer. ER -