TY - JOUR T1 - Hepatic Arterial Infusion Chemotherapy Is a Feasible Treatment Option for Breast Cancer with Liver-predominant Metastatic Disease JF - In Vivo JO - In Vivo SP - 1635 LP - 1641 DO - 10.21873/invivo.11425 VL - 32 IS - 6 AU - JUI-HU HSIAO AU - HONG-TAI CHANG AU - YEN-DUN TSENG AU - CHIA-LING CHIANG AU - I-SHU CHEN AU - YU-CHIA CHEN AU - PO-MING CHANG AU - BEING-WHEY WANG Y1 - 2018/11/01 UR - http://iv.iiarjournals.org/content/32/6/1635.abstract N2 - Background: Patients with liver metastasis from breast cancer (LMBC) are usually offered systemic therapy. However, for those with progressive liver disease and limited extra-hepatic conditions, local liver management becomes an option. Herein we present our experience with hepatic arterial infusion chemotherapy (HAIC). Patients and Methods: From 1999 to 2018, 42 patients with LMBC, who had progressive liver metastasis after systemic therapy, were treated with HAIC. A catheter was placed angiographically into the hepatic artery and remained there for 5 consecutive days. One cycle of chemotherapy consisted of mitoxantrone, 5-fluorouracil, folinic acid, and cisplatin. This treatment was repeated at monthly intervals. The medical records were reviewed and analyzed for hepatic tumor response, progression-free survival, overall survival and adverse effects. Results: Complete response was observed in two patients (5%), partial response in 18 patients (43%) and stable disease in eight patients (19%). Fourteen patients (33%) had progressive disease after HAIC. The median progression-free survival and overall survival were 8.4 and 19.3 months, respectively. There was no death related to HAIC. The patients with response to the treatment had a significant survival benefit (p<0.005). Conclusion: HAIC can be an option for those with progressive liver disease who are heavily pretreated while their extra-hepatic conditions are minimal or stable. ER -