RT Journal Article
SR Electronic
T1 Diagnostic Accuracy of Muscle Biopsy and Electromyography in 123 Patients with Neuromuscular Disorders
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1647
OP 1652
DO 10.21873/invivo.11427
VO 32
IS 6
A1 VASILIOS C. CONSTANTINIDES
A1 MARIA MARTHA PAPAHATZAKI
A1 GEORGIOS K. PAPADIMAS
A1 NIKOS KARANDREAS
A1 THOMAS ZAMBELIS
A1 PANAGIOTIS KOKOTIS
A1 PANAGIOTA MANDA
YR 2018
UL http://iv.iiarjournals.org/content/32/6/1647.abstract
AB Background/Aim: Diagnostic accuracy of muscle biopsy and electromyography (EMG) in patients with myopathy varies widely among studies. The goal of this study was to examine the diagnostic accuracy of each method in the diagnosis of patients with suspected myopathy, and determine the level of agreement between the two methods. Patients and Methods: The files of all patients with a presumed myopathy were retrospectively reviewed. All patients with detailed muscle biopsy and EMG data were included. Results: A total of 123 patients were included. Accuracy of biopsy was 80.4% compared to 70.7% for EMG. Biopsy was sensitive and specific in all neuromuscular disorders. EMG was accurate in neurogenic disorders. Biopsy and EMG agreement was 70.7%. Conclusion: Muscle biopsy is more accurate than EMG in patients with myopathy. Muscle biopsy–EMG discordance can be attributed to different muscle sampling and to disorders with both neurogenic and myopathic features, such as acquired and mitochondrial myopathies.