PT  - JOURNAL ARTICLE
AU  - VASILIOS C. CONSTANTINIDES
AU  - MARIA MARTHA PAPAHATZAKI
AU  - GEORGIOS K. PAPADIMAS
AU  - NIKOS KARANDREAS
AU  - THOMAS ZAMBELIS
AU  - PANAGIOTIS KOKOTIS
AU  - PANAGIOTA MANDA
TI  - Diagnostic Accuracy of Muscle Biopsy and Electromyography in 123 Patients with Neuromuscular Disorders
AID  - 10.21873/invivo.11427
DP  - 2018 Nov 01
TA  - In Vivo
PG  - 1647--1652
VI  - 32
IP  - 6
4099  - http://iv.iiarjournals.org/content/32/6/1647.short
4100  - http://iv.iiarjournals.org/content/32/6/1647.full
SO  - In Vivo2018 Nov 01; 32
AB  - Background/Aim: Diagnostic accuracy of muscle biopsy and electromyography (EMG) in patients with myopathy varies widely among studies. The goal of this study was to examine the diagnostic accuracy of each method in the diagnosis of patients with suspected myopathy, and determine the level of agreement between the two methods. Patients and Methods: The files of all patients with a presumed myopathy were retrospectively reviewed. All patients with detailed muscle biopsy and EMG data were included. Results: A total of 123 patients were included. Accuracy of biopsy was 80.4% compared to 70.7% for EMG. Biopsy was sensitive and specific in all neuromuscular disorders. EMG was accurate in neurogenic disorders. Biopsy and EMG agreement was 70.7%. Conclusion: Muscle biopsy is more accurate than EMG in patients with myopathy. Muscle biopsy–EMG discordance can be attributed to different muscle sampling and to disorders with both neurogenic and myopathic features, such as acquired and mitochondrial myopathies.