RT Journal Article
SR Electronic
T1 Evaluation of Porcine Hybrid Bone Block for Bone Grafting in Dentistry
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1419
OP 1426
DO 10.21873/invivo.11394
VO 32
IS 6
A1 SE EUN KIM
A1 EUNSEOK LEE
A1 KWANGSIK JANG
A1 KYUNG MI SHIM
A1 SEONG SOO KANG
YR 2018
UL http://iv.iiarjournals.org/content/32/6/1419.abstract
AB Background/Aim: The purpose of this study was to develop hybrid bone blocks using porcine-derived collagen and low crystalline porcine-derived hydroxyapatite to overcome the disadvantages of commonly used bone grafts in dentistry. Materials and Methods: Collagen was added to hydroxyapatite particles to increase the spatial integration of particulate bone grafts. Physicochemical examination and in vivo tests were performed to analyze scaffold's characteristics and evaluate bone regeneration. Results: Porcine hybrid bone block had an irregular and interconnecting macroporous structure that was adequate for bone regeneration and bone ingrowth, and showed a good space-occupying ability to become well positioned. In addition, it showed higher angiogenesis and biodegradability than Bio-Oss Collagen®, a commercialized bone graft used in dental clinics. Conclusion: Our results suggest that improved collagen hybrid bone block can be generated when porcine cancellous bone particles and collagen were reasonably mixed. This hybrid bone block was easy in handling had flexibility, good biodegradability and provided bone regeneration.