RT Journal Article SR Electronic T1 Histological Grade: Analysis of Prognosis of Non-small Cell Lung Cancer After Complete Resection JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 1505 OP 1512 DO 10.21873/invivo.11407 VO 32 IS 6 A1 MOTOAKI YASUKAWA A1 NORIYOSHI SAWABATA A1 TAKESHI KAWAGUCHI A1 NORIKAZU KAWAI A1 TOKIKO NAKAI A1 CHIHO OHBAYASHI A1 SHIGEKI TANIGUCHI YR 2018 UL http://iv.iiarjournals.org/content/32/6/1505.abstract AB Background/Aim: Although the 2015 World Health Organization Classification reported that histological grading may be helpful in lung cancer management, a widely accepted histological grading system with clearly defined criteria and demonstrable clinical significance has not been developed. We investigated the prognoses of patients with resected non-small cell lung cancer (NSCLC) to identify prognostic factors, especially histological grade. Materials and Methods: The medical records of 531 patients between 2010 and 2015 were retrospectively reviewed. Overall survival (OS) curve was plotted using the Kaplan–Meier method. Cox regression analyses were used to evaluate the hazard ratio (HR) with endpoint of OS. Results: The 5-year OS rate in groups with histological grade 1, grade 2, and grade 3+4 groups was 95.8%, 85.7%, and 72.1%, respectively (p<0.001). Multivariate analysis identified histological grade and vascular invasion as independent predictors of OS [histological grade: HR=1.533, p=0.002]. Conclusion: Histological grade was an independent prognostic factor of patients resected for all stages of NSCLC.