%0 Journal Article %A BALÁZS NÉMETH %A ISTVÁN KISS %A BELLA AJTAY %A IVÁN PÉTER %A ZITA KRESKA %A ATTILA CZIRÁKI %A IVÁN G. HORVÁTH %A ZÉNÓ AJTAY %T Transcutaneous Carbon Dioxide Treatment Is Capable of Reducing Peripheral Vascular Resistance in Hypertensive Patients %D 2018 %R 10.21873/invivo.11414 %J In Vivo %P 1555-1559 %V 32 %N 6 %X Aim: We aimed to investigate the effects of a single carbon dioxide (CO2) treatment on arterial stiffness by monitoring the changes of aortic pulse-wave velocity (PWV) and aortic augmentation index (AIXao), which are indicators of arterial stiffness. Patients and Methods: PWV and AIXao were measured by an invasively validated oscillometric device. The measurements of stiffness parameters were performed before the CO2 treatment, and at 1, 4 and 8 h after the first treatment. Results: Thirty-one patients were included. No significant changes were found in PWV. AIXao decreased significantly 1 h and 4 h after CO2 treatment compared to baseline values (p=0.034 and p<0.001). AIXao increased 8 h after the CO2 treatment, but remained significantly lower than baseline AIXao values (p=0.016). Conclusion: CO2 treatment is capable of reducing peripheral vascular resistance. We hypothesize that CO2 is not only a temporal vasodilator but is also capable of activating vasodilation pathways. %U https://iv.iiarjournals.org/content/invivo/32/6/1555.full.pdf