TY - JOUR T1 - The Relationship Between Sepsis-induced Immunosuppression and Serum Toll-like Receptor 9 Level JF - In Vivo JO - In Vivo SP - 1653 LP - 1658 DO - 10.21873/invivo.11428 VL - 32 IS - 6 AU - NAZAN ATALAN AU - LEYLA ACAR AU - NIHAN YAPICI AU - TURKAN KUDSIOGLU AU - ARZU ERGEN AU - SEDA GULEC YILMAZ AU - TURGAY ISBIR Y1 - 2018/11/01 UR - http://iv.iiarjournals.org/content/32/6/1653.abstract N2 - Background/Aim: Our aim was to determine serum TLR-9 levels in sepsis and evaluate the relationship between sepsis and serum TLR-9 levels. Materials and Methods: The study group consisted of 80 consecutive patients with sepsis and 100 healthy individuals. The demographic characteristics, co-morbidities and hemodynamic data of all patients were recorded. Results: TLR-9 serum levels in sepsis were statistically significantly lower compared to the control group. It was also seen that when the lactate level was >5 mmol/l in patients in the sepsis group, the serum TLR-9 levels were substantially higher. Conclusion: There is a relationship between sepsis-induced immunosuppression and serum TLR-9 levels. The host immunity system can be activated by means of TLR-9-related systems, while hyperlactatemia may play a stimulating role in the re-activation of the immune system. ER -