%0 Journal Article %A JOANNA ZAWITKOWSKA %A MONIKA LEJMAN %A AGNIESZKA ZAUCHA-PRAŻMO %A KATARZYNA DRABKO %A MARCIN PŁONOWSKI %A JOANNA BULSA %A MICHAŁ ROMISZEWSKI %A AGNIESZKA MIZIA-MALARZ %A ANDRZEJ KOŁTAN %A KATARZYNA DERWICH %A GRAŻYNA KAROLCZYK %A TOMARZ OCIEPA %A MAGDALENA ĆWIKLIŃSKA %A JOANNA TRELIŃSKA %A JOANNA OWOC-LEMPACH %A MACIEJ NIEDŹWIECKI %A ALEKSANDRA KIERMASZ %A JERZY KOWALCZYK %T Grade 3 and 4 Toxicity Profiles During Therapy of Childhood Acute Lymphoblastic Leukemia %D 2019 %R 10.21873/invivo.11608 %J In Vivo %P 1333-1339 %V 33 %N 4 %X Background/Aim: The risk factors, clinical features and non-hematological toxicity profiles during chemotherapy in acute lymphoblastic leukemia (ALL) patients treated in pediatric hematology centres were analysed. Materials and Methods: A total of 902/1872 children were reported as having grade 3 or 4 toxicity. Results: Among the analysed toxicities, infection and gastrointestinal and liver toxicities were the most common. The median follow-up was 6.8 years. Overall survival and event-free survival rates for the analysed group were lower than those reported for the group without grade ≥3 toxicity. In univariate analysis, we identified the number of toxic episodes, the risk group and remission status that had a significant impact on the outcome. Multivariate analysis demonstrated the risk group and the number of toxic episodes ≥3 to be statistically significant for the results. Conclusion: The toxic profiles investigated in our report should be used in future efforts to decrease the burden of side effects during chemotherapy. %U https://iv.iiarjournals.org/content/invivo/33/4/1333.full.pdf