TY - JOUR T1 - Grade 3 and 4 Toxicity Profiles During Therapy of Childhood Acute Lymphoblastic Leukemia JF - In Vivo JO - In Vivo SP - 1333 LP - 1339 DO - 10.21873/invivo.11608 VL - 33 IS - 4 AU - JOANNA ZAWITKOWSKA AU - MONIKA LEJMAN AU - AGNIESZKA ZAUCHA-PRAŻMO AU - KATARZYNA DRABKO AU - MARCIN PŁONOWSKI AU - JOANNA BULSA AU - MICHAŁ ROMISZEWSKI AU - AGNIESZKA MIZIA-MALARZ AU - ANDRZEJ KOŁTAN AU - KATARZYNA DERWICH AU - GRAŻYNA KAROLCZYK AU - TOMARZ OCIEPA AU - MAGDALENA ĆWIKLIŃSKA AU - JOANNA TRELIŃSKA AU - JOANNA OWOC-LEMPACH AU - MACIEJ NIEDŹWIECKI AU - ALEKSANDRA KIERMASZ AU - JERZY KOWALCZYK Y1 - 2019/07/01 UR - http://iv.iiarjournals.org/content/33/4/1333.abstract N2 - Background/Aim: The risk factors, clinical features and non-hematological toxicity profiles during chemotherapy in acute lymphoblastic leukemia (ALL) patients treated in pediatric hematology centres were analysed. Materials and Methods: A total of 902/1872 children were reported as having grade 3 or 4 toxicity. Results: Among the analysed toxicities, infection and gastrointestinal and liver toxicities were the most common. The median follow-up was 6.8 years. Overall survival and event-free survival rates for the analysed group were lower than those reported for the group without grade ≥3 toxicity. In univariate analysis, we identified the number of toxic episodes, the risk group and remission status that had a significant impact on the outcome. Multivariate analysis demonstrated the risk group and the number of toxic episodes ≥3 to be statistically significant for the results. Conclusion: The toxic profiles investigated in our report should be used in future efforts to decrease the burden of side effects during chemotherapy. ER -