RT Journal Article
SR Electronic
T1 Chemoradiotherapy for Local Recurrence of Rectal Cancer: A Single Center Study of 18 Patients
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1363
OP 1368
DO 10.21873/invivo.11612
VO 33
IS 4
A1 JUNKO WATANABE
A1 HIROKAZU SHOJI
A1 TETSUYA HAMAGUCHI
A1 TAKAHIRO MIYAMOTO
A1 HIDEKAZU HIRANO
A1 SATORU IWASA
A1 YOSHITAKA HONMA
A1 ATSUO TAKASHIMA
A1 KEN KATO
A1 YOSHINORI ITO
A1 JUN ITAMI
A1 YUKIHIDE KANEMITSU
A1 NARIKAZU BOKU
YR 2019
UL http://iv.iiarjournals.org/content/33/4/1363.abstract
AB Background/Aim: When possible, surgical resection is recommended for local recurrence after resection of colorectal cancer. In unresectable cases, chemotherapy is usually indicated, although the success of chemoradiotherapy (CRT) in this setting is unclear. Patients and Methods: We retrospectively reviewed the treatment outcomes of 18 patients who received CRT for unresectable local recurrence after radical colorectal cancer surgery at our hospital between January 2000 and May 2016. Results: Of these 18 patients, three experienced complete response and four experienced partial response, resulting in a 39% overall response. With a median follow-up time of 42 months, the 5-year progression-free survival and overall survival were 34.8% and 54.4%, respectively; associated with a median local failure-free survival time of 40.9 months. Two of the three patients that underwent CRT remained local failure free for 5 years. Conclusion: CRT for local recurrence of rectal cancer without distant metastasis produces similar overall survival rates and local control as conventional surgical resection.