TY - JOUR T1 - A Regenerative Endodontic Approach in Mature Ferret Teeth Using Rodent Preameloblast-conditioned Medium JF - In Vivo JO - In Vivo SP - 1143 LP - 1150 DO - 10.21873/invivo.11584 VL - 33 IS - 4 AU - CRISTINA BUCCHI AU - ÁLVARO GIMENO-SANDIG AU - IVÁN VALDIVIA-GANDUR AU - CRISTINA MANZANARES-CÉSPEDES AU - JOSEP MARIA DE ANTA Y1 - 2019/07/01 UR - http://iv.iiarjournals.org/content/33/4/1143.abstract N2 - Background: This study evaluated the effectiveness of a regenerative endodontic approach to regenerate the pulp tissue in mature teeth of ferret. The presence of odontoblast-like cells in the newly-formed tissue of teeth treated with or without preameloblast-conditioned medium was evaluated based on morphological criteria. Materials and Methods: Twenty-four canines from six ferrets were treated. The pulp was removed, and the apical foramen was enlarged. After inducing the formation of a blood clot, a collagen sponge with or without preameloblast-conditioned medium was placed underneath the cementoenamel junction. The samples were analyzed at the eighth week of follow-up. Results: Vascularized connective tissue was observed in 50% of teeth, without differences between groups. The tissue occupied the apical third of the root canals. Odontoblast-like cells were not observed in any group. Conclusion: Revitalization of mature teeth is possible, at least in the apical third of the root canal. Further experimental research is needed to produce more reliable outcomes. ER -