PT  - JOURNAL ARTICLE
AU  - BUCCHI, CRISTINA
AU  - GIMENO-SANDIG, ÁLVARO
AU  - VALDIVIA-GANDUR, IVÁN
AU  - MANZANARES-CÉSPEDES, CRISTINA
AU  - DE ANTA, JOSEP MARIA
TI  - A Regenerative Endodontic Approach in Mature Ferret Teeth Using Rodent Preameloblast-conditioned Medium
AID  - 10.21873/invivo.11584
DP  - 2019 Jul 01
TA  - In Vivo
PG  - 1143--1150
VI  - 33
IP  - 4
4099  - http://iv.iiarjournals.org/content/33/4/1143.short
4100  - http://iv.iiarjournals.org/content/33/4/1143.full
SO  - In Vivo2019 Jul 01; 33
AB  - Background: This study evaluated the effectiveness of a regenerative endodontic approach to regenerate the pulp tissue in mature teeth of ferret. The presence of odontoblast-like cells in the newly-formed tissue of teeth treated with or without preameloblast-conditioned medium was evaluated based on morphological criteria. Materials and Methods: Twenty-four canines from six ferrets were treated. The pulp was removed, and the apical foramen was enlarged. After inducing the formation of a blood clot, a collagen sponge with or without preameloblast-conditioned medium was placed underneath the cementoenamel junction. The samples were analyzed at the eighth week of follow-up. Results: Vascularized connective tissue was observed in 50% of teeth, without differences between groups. The tissue occupied the apical third of the root canals. Odontoblast-like cells were not observed in any group. Conclusion: Revitalization of mature teeth is possible, at least in the apical third of the root canal. Further experimental research is needed to produce more reliable outcomes.