RT Journal Article SR Electronic T1 Association of Caspase-8 Genotypes With Oral Cancer Risk in Taiwan JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 1151 OP 1156 DO 10.21873/invivo.11585 VO 33 IS 4 A1 LIANG-CHUN SHIH A1 CHIA-WEN TSAI A1 KUO-TING SUN A1 HUAI-MEI HSU A1 TE-CHUN SHEN A1 YUEH-TING TSAI A1 WEN-SHIN CHANG A1 MENG-LIANG LIN A1 YUN-CHI WANG A1 CHI-LI GONG A1 DA-TIAN BAU YR 2019 UL http://iv.iiarjournals.org/content/33/4/1151.abstract AB Background/Aim: Recently, mounting evidence has shown that caspase-8 (CASP8) rs3834129 (-652, 6N insertion/deletion) polymorphism may serve as a genetic biomarker for personal risk of various cancer types. The contribution of CASP8 rs3834129 polymorphism has been investigated in several oral cancer populations, but not in Taiwan. This study investigated the role of CASP8 rs3834129 polymorphism on oral risk in Taiwan. Materials and Methods: CASP8 rs3834129 polymorphic genotypes were determined and their associations with oral cancer risk were investigated among 788 patients with oral cancer and 956 age- and gender-matched healthy controls via polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) methodology. In addition, the interaction of CASP8 rs3834129 genotype with personal behavior and clinicopathological features were also examined. Results: The frequencies of II, ID and DD genotypes for CASP8 rs3834129 were 57.5, 36.5 and 6.0% in the patient group and 54.0, 39.0 and 7.0% in the healthy control group, respectively (p for trend=0.3052), genotypes were not significantly differentially distributed between the two groups. The comparisons in allelic frequency distribution also supported the findings that the D variant allele may not serve as a determinant of risk for oral cancer. There was no interaction of CASP8 rs3834129 genotype with age, gender, smoking, alcohol or betel quid consumption in regard to oral cancer risk. Conclusion: Our results indicate that the caspase-8 genotype does not appear to play a direct role in personal susceptibility to oral cancer in Taiwan.