PT  - JOURNAL ARTICLE
AU  - KATARZYNA GAWRON
AU  - WOJCIECH WOJTOWICZ
AU  - KATARZYNA ŁAZARZ-BARTYZEL
AU  - AGATA ŁAMASZ
AU  - BADR QASEM
AU  - PIOTR MYDEL
AU  - MARIA CHOMYSZYN-GAJEWSKA
AU  - JAN POTEMPA
AU  - PIOTR MLYNARZ
TI  - Metabolomic Status of The Oral Cavity in Chronic Periodontitis
AID  - 10.21873/invivo.11587
DP  - 2019 Jul 01
TA  - In Vivo
PG  - 1165--1174
VI  - 33
IP  - 4
4099  - http://iv.iiarjournals.org/content/33/4/1165.short
4100  - http://iv.iiarjournals.org/content/33/4/1165.full
SO  - In Vivo2019 Jul 01; 33
AB  - Chronic periodontitis is an inflammatory disease of tooth-supporting tissues associated with Porphyromonas gingivalis. Expansion and invasion of this bacterium into the periodontium is associated with changes in the metabolome of the oral cavity. Materials and Methods: Metabolomics analysis of mouth washout and tongue swab samples based on proton nuclear magnetic resonance (1H-NMR) method was employed to determine metabolic status of the oral cavity in chronic periodontal disease. Results: Mouth washout extracts contained a total of 23 metabolites and tongue swab extracts contained 17. Identified metabolites partially overlap with the content of saliva and gingival crevicular fluid. The colonization of the oral cavity of patients with periodontitis by bacteria was manifested in the change in levels of eight metabolites. Conclusion: NMR-based metabolomics analysis is a potentially useful methodological approach for monitoring the pathological processes observed in the oral cavity in the course of periodontitis.