RT Journal Article SR Electronic T1 Grid-climbing Behaviour as a Pain Measure for Cancer-induced Bone Pain and Neuropathic Pain JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 619 OP 623 VO 31 IS 4 A1 SARAH FALK A1 SIMONE GALLEGO-PEDERSEN A1 NICOLAS C. PETERSEN YR 2017 UL http://iv.iiarjournals.org/content/31/4/619.abstract AB Despite affecting millions of people, chronic pain is generally treated insufficiently. A major point of focus has been the lack of translation from preclinical data to clinical results, with the predictive value of chronic pain models being a major concern. In contrast to current focus on stimulus-based nociceptive responses in preclinical research, development of behavioural tests designed to quantify suspension of normal behaviour is likely a more equivalent readout for human pain-assessment tests. In this study, we quantified grid-climbing behaviour as a non-stimulus-evoked behavioural test for potential use as a measure of neuropathic and cancer-induced bone pain in mice. In both models, the grid-climbing test demonstrated pain-related sparing of the affected leg during climbing. In both models, the behaviour was reversed by administration of morphine, suggesting that the observed behaviour was pain-specific.