RT Journal Article SR Electronic T1 MicroRNA-1 and MicroRNA-21 Individually Regulate Cellular Growth of Non-malignant and Malignant Renal Cells JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 625 OP 630 VO 31 IS 4 A1 HANNES AHREND A1 ANNE KAUL A1 SUSANNE ZIEGLER A1 LARS-OVE BRANDENBURG A1 UWE ZIMMERMANN A1 ALEXANDER MUSTEA A1 MARTIN BURCHARDT A1 PATRICK ZIEGLER A1 MATTHIAS B. STOPE YR 2017 UL http://iv.iiarjournals.org/content/31/4/625.abstract AB Background/Aim: Due to its poor prognosis, it is increasingly necessary to understand the biology of renal cell cancer (RCC). Therefore, we investigated the role of microRNAs miR-1 and miR-21 in the growth of RCC cells compared to that of non-malignant renal cells. Materials and Methods: Four malignant cell lines (Caki-1, 786-O, RCC4, A498) were examined regarding their cell growth, microRNA and telomerase expression, and were compared to non-malignant RC-124 renal cells. Results: Inconsistencies appeared in the panel of RCC cells regarding antiproliferative and proliferative properties of miR-1 and miR-21, respectively. Notably, and most likely due to immortaliziation, non-malignant RC-124 cells exhibited telomerase expression and activity. Conclusion: miR-1 and miR-21 functionality in cancer progression, particularly in tumor growth, may be more dependent on the individual cellular context and may reflect RCC heterogeneity. Thus, both microRNAs, in combination with other stratifying biomarkers, may be useful in terms of RCC diagnosis, prognosis, or treatment response.