RT Journal Article
SR Electronic
T1 Maximum Diameter and Number of Tumors as a New Prognostic Indicator of Colorectal Liver Metastases
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 419
OP 423
VO 31
IS 3
A1 YOSHIMOTO, TOSHIAKI
A1 MORINE, YUJI
A1 IMURA, SATORU
A1 IKEMOTO, TETSUYA
A1 IWAHASHI, SYUICHI
A1 SAITO, YU
A1 YAMADA, SINICHIRO
A1 ISHIKAWA, DAICHI
A1 TERAOKU, HIROKI
A1 YOSHIKAWA, MASATO
A1 HIGASHIJIMA, JUN
A1 TAKASU, CHIE
A1 SHIMADA, MITSUO
YR 2017
UL http://iv.iiarjournals.org/content/31/3/419.abstract
AB Background: Surgical resection is currently considered the only potentially curative option as a treatment strategy of colorectal liver metastases (CRLM). However, the criteria for selection of resectable CRLM are not clear. The aim of this study was to confirm a new prognostic indicator of CRLM after hepatic resection. Patients and Methods: One hundred thirty nine patients who underwent initial surgical resection from 1994 to 2015 were investigated retrospectively. Prognostic factors of overall survival including the product of maximum diameter and number of metastases (MDN) were analyzed. Results: Primary tumor differentiation, vessel invasion, lymph node (LN) metastasis, non-optimally resectable metastases, H score, grade of liver metastases, resection with non-curative intent and MDN were found to be prognostic factors of overall survival (OS). In multivariate analyses of clinicopathological features associated with OS, MDN and non-curative intent were independent prognostic factors. Patients with MDN ≥30 had shown significantly poorer prognosis than patients with MDN <30 in OS and relapse-free survival (RFS). Conclusion: MDN ≥30 is an independent prognostic factor of survival in patients with CRLM and optimal surgical criterion of hepatectomy for CRLM.