PT  - JOURNAL ARTICLE
AU  - TOSHIAKI YOSHIMOTO
AU  - YUJI MORINE
AU  - SATORU IMURA
AU  - TETSUYA IKEMOTO
AU  - SYUICHI IWAHASHI
AU  - YU SAITO
AU  - SINICHIRO YAMADA
AU  - DAICHI ISHIKAWA
AU  - HIROKI TERAOKU
AU  - MASATO YOSHIKAWA
AU  - JUN HIGASHIJIMA
AU  - CHIE TAKASU
AU  - MITSUO SHIMADA
TI  - Maximum Diameter and Number of Tumors as a New Prognostic Indicator of Colorectal Liver Metastases
DP  - 2017 May 01
TA  - In Vivo
PG  - 419--423
VI  - 31
IP  - 3
4099  - http://iv.iiarjournals.org/content/31/3/419.short
4100  - http://iv.iiarjournals.org/content/31/3/419.full
SO  - In Vivo2017 May 01; 31
AB  - Background: Surgical resection is currently considered the only potentially curative option as a treatment strategy of colorectal liver metastases (CRLM). However, the criteria for selection of resectable CRLM are not clear. The aim of this study was to confirm a new prognostic indicator of CRLM after hepatic resection. Patients and Methods: One hundred thirty nine patients who underwent initial surgical resection from 1994 to 2015 were investigated retrospectively. Prognostic factors of overall survival including the product of maximum diameter and number of metastases (MDN) were analyzed. Results: Primary tumor differentiation, vessel invasion, lymph node (LN) metastasis, non-optimally resectable metastases, H score, grade of liver metastases, resection with non-curative intent and MDN were found to be prognostic factors of overall survival (OS). In multivariate analyses of clinicopathological features associated with OS, MDN and non-curative intent were independent prognostic factors. Patients with MDN ≥30 had shown significantly poorer prognosis than patients with MDN <30 in OS and relapse-free survival (RFS). Conclusion: MDN ≥30 is an independent prognostic factor of survival in patients with CRLM and optimal surgical criterion of hepatectomy for CRLM.