<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">EPPERLY, MICHAEL W.</style></author><author><style face="normal" font="default" size="100%">ZHANG, XICHEN</style></author><author><style face="normal" font="default" size="100%">FISHER, RENEE</style></author><author><style face="normal" font="default" size="100%">HOU, WEN</style></author><author><style face="normal" font="default" size="100%">FRANICOLA, DARCY</style></author><author><style face="normal" font="default" size="100%">SHIELDS, DONNA</style></author><author><style face="normal" font="default" size="100%">QUICKEL, MICHAEL</style></author><author><style face="normal" font="default" size="100%">HANKEY-GIBLIN, PAMELA</style></author><author><style face="normal" font="default" size="100%">WANG, HONG</style></author><author><style face="normal" font="default" size="100%">GREENBERGER, JOEL S.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Reduced Competitive Repopulation Capacity of Multipotential Hematopoietic Stem Cells in the Bone Marrow of Friend Virus-infected Fv2-resistant Mice</style></title><secondary-title><style face="normal" font="default" size="100%">In Vivo</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2017-05-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">313-320</style></pages><volume><style face="normal" font="default" size="100%">31</style></volume><issue><style face="normal" font="default" size="100%">3</style></issue><abstract><style  face="normal" font="default" size="100%">Background/Aim: The polycythemia form of Friend leukemia virus (FVP) causes splenomegaly and lethal erythroleukemia in Fv-2s-susceptible mouse strains. We sought to determine whether the hematopoietic stem cell (HSC) pool was expanded in Fv-2r-resistant mice. Materials and Methods: The 120-day bone marrow transplantation competitive repopulation assay was used to determine whether FVP-infected Fv-2r C57BL/6 mice demonstrated expansion of the HSC pool compared to the pool of committed hematopoietic progenitor cells in the same marrow assayed in vitro. Results: There was a significant expansion of committed hematopoietic progenitors observed in virus-infected Fv-2s FVB mice, but not Fv-2r C57BL/6 mice. Furthermore, Fv-2r mice showed no detectable expansion of either committed hematopoietic progenitor cells or the multipotential stem cell pool by competitive repopulation assay. Conclusion: Friend virus disease in Fv-2s mice is associated with expansion of committed hematopoietic progenitors. Fv-2r mice show no expansion of either committed progenitor or pluripotential stem cell numbers.</style></abstract></record></records></xml>