RT Journal Article
SR Electronic
T1 The Effect of Geraniol on Liver Regeneration After Hepatectomy in Rats
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 209
OP 213
VO 31
IS 2
A1 CANBEK, MEDIHA
A1 UYANOGLU, MUSTAFA
A1 CANBEK, SELCUK
A1 CEYHAN, EMRE
A1 OZEN, AHMET
A1 DURMUS, BASAK
A1 TURGAK, OZGE
YR 2017
UL http://iv.iiarjournals.org/content/31/2/209.abstract
AB Geraniol is a monoterpenoid alcohol that has a hepatoprotective effect. We investigated the regenerative effects of geraniol in rats after a 70% partial hepatectomy (PH). Using Wistar albino rats, nine groups were created: Group I was the control group, while the remaining groups received a single intraperitoneal dose of saline, Silymarin, or geraniol after PH. A 70% PH was performed on all groups except for groups II and III. Blood serum samples were obtained for alanine amino transferase (ALT) analysis. Then liver tissues were harvested for histological and real-time polymerase chain reaction (PCR) analyses. Tumor necrosis factor-α (TNFα) and interleukin 6 (IL6) gene expression were examined 24 and 48 h after PH. ALT levels were found to be statistically significantly increased in all PH-treated groups. TNFα and IL6 gene expression levels were elevated in geraniol-treated groups. Histological evaluation revealed a hepatoprotective effect for geraniol-treated groups. Our results suggest that geraniol plays a significant role during liver regeneration, which involves the elevated expression of TNFα and IL6 48 h after PH.