@article {ARIMURA265, author = {EMI ARIMURA and HIDEAKI OKATANI and TOMOAKI ARAKI and MIHARU USHIKAI and MIWA NAKAKUMA and MASAHARU ABE and HIROAKI KAWAGUCHI and HIROYUKI IZUMI and MASAHISA HORIUCHI}, title = {Effects of Diets with Different Proportions of Protein/Carbohydrate on Retinal Manifestations in db Mice}, volume = {32}, number = {2}, pages = {265--272}, year = {2018}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Diabetic nephropathy is aggravated by a higher intake of total protein. The effects of diets with different proportions of protein and carbohydrate on diabetic retinopathy in db mice, a type-2 diabetes animal model, were examined, as well as diabetic nephropathy. Materials and Methods: Control and db mice at 5 weeks of age were fed the diets (\% energy of protein/carbohydrate/fat; L-diet: 12/71/17; H-diet: 24/59/17) under ad libitum conditions and pair-feeding conditions for 6 weeks, respectively. Results: Mice fed the H-diet showed significantly greater retinal thickness by optical coherence tomography, and lower mRNA levels of angiotensinogen. Comparing combinations of diets and genotypes, db-H mice showed significantly higher mRNA levels of angiotensin-converting enzyme, advanced glycosylation end product-specific receptor, and cluster of differentiation molecule 11b (a microglial marker) than db-L mice. Conclusion: Dietary protein and carbohydrate proportions influenced retinal manifestations, including retinal thickness and gene expression in control and diabetic mice.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/32/2/265}, eprint = {https://iv.iiarjournals.org/content/32/2/265.full.pdf}, journal = {In Vivo} }