PT - JOURNAL ARTICLE AU - CHLOE CONSTANTINOU AU - SAVVAS PAPADOPOULOS AU - EIRINI KARYDA AU - ATHANASIOS ALEXOPOULOS AU - NIKI AGNANTI AU - ANNA BATISTATOU AU - HARIS HARISIS TI - Expression and Clinical Significance of Claudin-7, PDL-1, PTEN, c-Kit, c-Met, c-Myc, ALK, CK5/6, CK17, p53, EGFR, Ki67, p63 in Triple-negative Breast Cancer–A Single Centre Prospective Observational Study DP - 2018 Mar 01 TA - In Vivo PG - 303--311 VI - 32 IP - 2 4099 - http://iv.iiarjournals.org/content/32/2/303.short 4100 - http://iv.iiarjournals.org/content/32/2/303.full SO - In Vivo2018 Mar 01; 32 AB - Background/Aim: To explore the relationship between p53, p63, c-kit, Ki67, cMet, claudin7, CK5/6, CK17, AR, PTEN, EGFR, ALK, PDL-1 and c-MYC expression with the clinicopathological features of triple- negative breast cancer. Materials and Methods: Immunohistochemistry was performed in 84 triple-negative breast cancer samples. Results: A statistically significant relationship between tumour grade and claudin-7 (p=0.004) and between protein p53 and positive lymph nodes (p=0.015) was found. High expression of claudin-7 (OR=65.8, 95%CI=4.35-995.19, p-value=0.003) and low expression of c-kit (OR=0.14, 95%CI=0.025-0.793, p-value=0.026) and protein p63 (OR=0.18 95%CI=0.035-0.978, p-value=0.047) was associated with higher tumour grade. Higher AR expression (OR=13.44, 95%CI=1.28-141.56, p-value=0.031) and lower expression of CK5/6 cytokeratins was found in patients with positive lymphovascular invasion (LVI) (OR=0.072, 95%CI=0.007-0.732, p-value=0.026). Only the cell proliferation index (Ki67) has been proven to be statistically significant for disease-free survival (p-value=0.0378), and overall survival (p-value=0.0186). Conclusion: High expression of claudin-7 and low expression of c-kit and protein p63 are associated with higher tumour grade. AR and CK5/6 expression seem to be important in LVI.