TY - JOUR T1 - The Impact of Exercise Training on Breast Cancer JF - In Vivo JO - In Vivo SP - 249 LP - 254 VL - 32 IS - 2 AU - KATARZYNA SIEWIERSKA AU - IWONA MALICKA AU - CHRISTOPHER KOBIERZYCKI AU - URSZULA PASLAWSKA AU - MAREK CEGIELSKI AU - JEDRZEJ GRZEGRZOLKA AU - ALEKSANDRA PIOTROWSKA AU - MARZENNA PODHORSKA-OKOLOW AU - PIOTR DZIEGIEL AU - MAREK WOZNIEWSKI Y1 - 2018/03/01 UR - http://iv.iiarjournals.org/content/32/2/249.abstract N2 - Background/Aim: Physical exercise is increasingly considered by many authors to be a factor reducing the risk of cancer development and premature cancer-related death. Data indicate higher cure rates and longer times of survival in cancer patients who regularly exercise. Materials and Methods: A total of 50 female Sprague-Dawley rats were used in the experiment. Animals at 1 month of age were intraperitoneally injected with N-methyl-N-nitrosourea. Three months following drug administration, rats underwent supervised physical training. The animals were divided into four groups: control untrained group and 3 groups trained with different intensities – i.e. low, moderate and high. Routine histopathological examination of tumors was performed and mitotic activity was assessed by immunohistochemical expression of the Ki-67 antigen. Results: Ki-67 antigen expression was observed in all analyzed tumors. The increase in Ki-67 antigen expression correlated positively with the increase in training intensity. Conclusion: It can be assumed that low-intensity physical training is safe for patients with breast cancer. However, moderate- and high-intensity training may induce tumor cell proliferation worsening patients' prognosis. ER -