PT  - JOURNAL ARTICLE
AU  - KATARZYNA SIEWIERSKA
AU  - IWONA MALICKA
AU  - CHRISTOPHER KOBIERZYCKI
AU  - URSZULA PASLAWSKA
AU  - MAREK CEGIELSKI
AU  - JEDRZEJ GRZEGRZOLKA
AU  - ALEKSANDRA PIOTROWSKA
AU  - MARZENNA PODHORSKA-OKOLOW
AU  - PIOTR DZIEGIEL
AU  - MAREK WOZNIEWSKI
TI  - The Impact of Exercise Training on Breast Cancer
DP  - 2018 Mar 01
TA  - In Vivo
PG  - 249--254
VI  - 32
IP  - 2
4099  - http://iv.iiarjournals.org/content/32/2/249.short
4100  - http://iv.iiarjournals.org/content/32/2/249.full
SO  - In Vivo2018 Mar 01; 32
AB  - Background/Aim: Physical exercise is increasingly considered by many authors to be a factor reducing the risk of cancer development and premature cancer-related death. Data indicate higher cure rates and longer times of survival in cancer patients who regularly exercise. Materials and Methods: A total of 50 female Sprague-Dawley rats were used in the experiment. Animals at 1 month of age were intraperitoneally injected with N-methyl-N-nitrosourea. Three months following drug administration, rats underwent supervised physical training. The animals were divided into four groups: control untrained group and 3 groups trained with different intensities – i.e. low, moderate and high. Routine histopathological examination of tumors was performed and mitotic activity was assessed by immunohistochemical expression of the Ki-67 antigen. Results: Ki-67 antigen expression was observed in all analyzed tumors. The increase in Ki-67 antigen expression correlated positively with the increase in training intensity. Conclusion: It can be assumed that low-intensity physical training is safe for patients with breast cancer. However, moderate- and high-intensity training may induce tumor cell proliferation worsening patients' prognosis.