TY - JOUR T1 - Effect of Benifuuki Tea on Cytochrome P450-mediated Metabolic Activity in Rats JF - In Vivo JO - In Vivo SP - 33 LP - 40 VL - 32 IS - 1 AU - TAKAHITO HIRAI AU - YUKI NISHIMURA AU - NORIMITSU KURATA AU - HOKUTO NAMBA AU - MARIKO IWASE AU - YURIKA GOMI AU - HIROMICHI TSUCHIYA AU - TOMOYUKI YAMAKAWA AU - YUJI KIUCHI Y1 - 2018/01/01 UR - http://iv.iiarjournals.org/content/32/1/33.abstract N2 - Background/Aim: Benifuuki tea has recently been used as an alternative therapy for pollinosis, and it may be consumed with pharmaceutical drugs. This study aimed to examine cytochrome P450 (CYP)-mediated food-drug interactions with Benifuuki tea in rats. Materials and Methods: The inhibitory effects of Benifuuki tea and (–)-epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3”Me) on CYP activities were evaluated in vitro. Midazolam pharmacokinetics was investigated after two treatments with Benifuuki tea. In an ex vivo study, CYP activities were determined after 1-week-treatment with the tea. Results: Benifuuki tea and EGCG3”Me inhibited CYP2D and CYP3A activities in a concentration-dependent manner in vitro. However, MDZ metabolism did not change by Benifuuki treatment in vivo and ex vivo. In contrast, CYP2D activity was decreased ex vivo. Conclusion: Normal intake of Benifuuki tea is not likely to cause food-drug interactions by CYP3A inhibition or induction. In contrast, Benifuuki tea consumption may lead to food-drug interactions through the inhibition of CYP2D. ER -