RT Journal Article
SR Electronic
T1 Inhibition of Formation of Azoxymethane-induced Colonic Aberrant Crypt Foci in Rats by Edible Green Algae <em>Capsosiphon fulvescens</em> and Brown Algae <em>Hizikia fusiforme</em>
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 101
OP 108
VO 32
IS 1
A1 YOUNG-SOOK SON
A1 H.M. ARIF ULLAH
A1 AHMED K. ELFADL
A1 SOONG-GU GHIM
A1 MYUNG-JIN CHUNG
A1 YONG DEUK KIM
A1 EUN-JOO LEE
A1 KYUNG-KU KANG
A1 KYU-SHIK JEONG
YR 2018
UL http://iv.iiarjournals.org/content/32/1/101.abstract
AB Capsosiphon fulvescens (green seaweed) and Hizikia fusiforme (brown seaweed) are marine algae consumed as food supplements, especially in Japan, China and Korea, and are considered traditional medicinal tonics for certain ailments. The aim of this study was to investigate the possible inhibitory effects of dietary C. fulvescens and H. fusiforme on azoxymethane (AOM)-induced colorectal cancer (CRC) in rats. F344 male rats (5 weeks, 150 g) were divided into six groups as follows. Group 1: Injected with normal saline solution and fed control diet (untreated control). Group 2: Injected with AOM and fed control diet (treated control). Group 3: Injected with AOM and fed 1% C. fulvescens diet. Group 4: Injected with AOM and fed 2% C. fulvescens diet. Group 5: Injected with AOM and fed 2% H. fusiforme diet. Group 6: Injected with AOM and fed 6% H. fusiforme diet. Test animals received subcutaneous injections of AOM (15 mg/1 ml/kg body weight) once a week for 2 weeks to induce aberrant crypt foci (ACF) in treated control and experimental groups. We evaluated the effects of dietary C. fulvescens and H. fusiforme at two different dose levels: 1 and 2% C. fulvescens, and 2 and 6% H. fusiforme, on colonic carcinogenesis by AOM in rats. Our results suggest that body weights were not significantly different amongst groups. We found that feeding C. fulvescens and H. fusiforme with a control diet significantly (p&lt;0.05) inhibited the development of ACF in experimental groups. C. fulvescens and H. fusiforme in food also significantly (p&lt;0.05) reduced the proliferating cell nuclear antigen labeling index in the colonic tissues of experimental groups. These results demonstrate the chemopreventive potential of C. fulvescens and H. fusiforme against CRC in an AOM-induced rats.