PT  - JOURNAL ARTICLE
AU  - MARINOS C. MAKRIS
AU  - ANDREAS ALEXANDROU
AU  - EFSTATHIOS G. PAPATSOUTSOS
AU  - GEORGE MALIETZIS
AU  - DIAMANTIS I. TSILIMIGRAS
AU  - ALFREDO D. GUERRON
AU  - DEMETRIOS MORIS
TI  - Ghrelin and Obesity: Identifying Gaps and Dispelling Myths. A Reappraisal
DP  - 2017 Nov 01
TA  - In Vivo
PG  - 1047--1050
VI  - 31
IP  - 6
4099  - http://iv.iiarjournals.org/content/31/6/1047.short
4100  - http://iv.iiarjournals.org/content/31/6/1047.full
SO  - In Vivo2017 Nov 01; 31
AB  - The etiology of obesity is complex. Environmental and genetic causes have been implicated in the development of this disease. Ghrelin is a hormone known to stimulate appetite. There are numerous possible actions through which ghrelin exerts its effect in the body: a) Overproduction of ghrelin, b) reduced ghrelin following meals, and c) increased receptor sensitivity to ghrelin action. Sleeve gastrectomy, a bariatric procedure, leads to reduction of ghrelin levels and subsequently to weight loss. However, there are many limitations to measurement of the fasting plasma level of the active form of ghrelin. The establishment of the exact correlation between ghrelin, appetite and obesity could be vital for the fight against obesity.