PT  - JOURNAL ARTICLE
AU  - STEFAN BAUMANN
AU  - MARLON RUTSCH
AU  - TOBIAS BECHER
AU  - PHILIPP KRYEZIU
AU  - HOLGER HAUBENREISSER
AU  - NILS VOGLER
AU  - CELI ANNE SCHOENIKE
AU  - MARTIN BORGGREFE
AU  - STEFAN O. SCHOENBERG
AU  - IBRAHIM AKIN
AU  - THOMAS HENZLER
AU  - DIRK LOSSNITZER
TI  - Clinical Impact of Rest Dual–energy Computed Tomography Myocardial Perfusion in Patients with Coronary Artery Disease
DP  - 2017 Nov 01
TA  - In Vivo
PG  - 1153--1157
VI  - 31
IP  - 6
4099  - http://iv.iiarjournals.org/content/31/6/1153.short
4100  - http://iv.iiarjournals.org/content/31/6/1153.full
SO  - In Vivo2017 Nov 01; 31
AB  - Background/Aim: To evaluate the hypothesis that patients with suspected coronary artery disease (CAD) assessed using rest dual-energy computed tomography-derived myocardial perfusion imaging (DECT-P), could have fewer invasive coronary angiographies (ICA), showing non-obstructive CAD. Materials and Methods: Patients who had undergone coronary computed tomography angiography (cCTA), rest DECT-P and ICA were analyzed. Results: We evaluated 51 patients (62.7% males, mean age 51.6±12.8 years). Rest DECT-P identified perfusion defects in three (10.7%) of the 28 patients with cCTA negative for luminal stenosis and in 10 (43.5%) of the 23 patients with cCTA positive for luminal stenosis. In total, 21 patients underwent both cCTA and ICA, of which seven (33.3%) showed obstructive CAD. Rest DECT-P revealed false-negative results in four cases (19.1%) and false-positive results in six cases (28.6%). Conclusion: Adding rest DECT-P to cCTA has no incremental diagnostic value over cCTA alone, to exclude haemodynamically significant CAD. Therefore, a rest-stress-DECT-P protocol or a CT-based FFR calculation might be a promising concept to improve diagnostic accuracy in a real clinical setting.