RT Journal Article
SR Electronic
T1 Predictive Factors of Late-onset Rectal Mucosal Changes After Radiotherapy of Prostate Cancer
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 961
OP 966
VO 31
IS 5
A1 EDY IPPOLITO
A1 ALESSANDRA GUIDO
A1 GABRIELLA MACCHIA
A1 FRANCESCO DEODATO
A1 LUCIA GIACCHERINI
A1 ANDREA FARIOLI
A1 ALESSANDRA ARCELLI
A1 DAJANA CUICCHI
A1 LEONARDO FRAZZONI
A1 SAVINO CILLA
A1 MILLY BUWENGE
A1 GIOVANNA MANTINI
A1 ANNA R. ALITTO
A1 MARIANNA NUZZO
A1 VINCENZO VALENTINI
A1 MARCELLO INGROSSO
A1 ALESSIO G. MORGANTI
A1 LORENZO FUCCIO
YR 2017
UL http://iv.iiarjournals.org/content/31/5/961.abstract
AB Background/Aim: The Vienna Rectoscopy Score (VRS; from 0, absence of rectal mucosal changes, to 5) assessed 1 year after radiotherapy is a surrogate end-point of late rectal toxicity. The aim of this study was to investigate the association between treatment-related factors and 1-year VRS. Patients and Methods: We performed a retrospective analysis of prospectively collected data. Patients with prostate adenocarcinoma treated with definitive or postoperative radiotherapy (RT) underwent endoscopy 1 year after RT. Relationships between VRS of 2 or more and treatment parameters were investigated by univariate and multivariate logistic analyses. Results: One hundred and ninety-five patients (mean age=69 years; range=43-81 years) were considered eligible for the study. At univariate analysis, patients treated with hypofractionation plus radiosurgery boost (p<0.001) and an equivalent dose in 2 Gy per fraction (EQD2) (α/β=3) ≥75 Gy (p<0.001) was associated with a significantly higher incidence of VRS ≥2 after 1 year of follow-up. At multivariate analysis, radiosurgery boost was an independent risk factor for developing rectal mucosal lesions (VRS ≥2), yielding an odds ratio (OR) of 4.14 (95% confidence interval (CI)=1.2-13.8), while pelvic surgery was inversely associated with VRS ≥2 (OR=0.39; 95% CI=0.17-0.94). Conclusion: Hypofractionation followed by radiosurgery boost significantly increased the risk of developing late-onset rectal mucosal changes. Therefore, special care and preventative treatment strategies are needed when using radiosurgery boost after hypofractionated RT.