TY - JOUR T1 - Rotating Gamma System Irradiation: A Promising Treatment for Low-grade Brainstem Gliomas JF - In Vivo JO - In Vivo SP - 957 LP - 960 VL - 31 IS - 5 AU - PHAM CAM PHUONG AU - NGUYEN QUANG HUNG AU - TRAN BAO NGOC AU - DIRK RADES AU - MAI TRONG KHOA Y1 - 2017/09/01 UR - http://iv.iiarjournals.org/content/31/5/957.abstract N2 - Aim: To evaluate the role of rotating gamma system (RGS) radiosurgery for low-grade brainstem gliomas. Patients and Methods: Thirty-seven patients undergoing RGS radiosurgery at the Bach Mai Hospital Hanoi for low-grade brainstem glioma were included in this prospective interventional study. The median RGS dose was 12 Gy (range=8-16 Gy). Endpoints included response to RGS radiosurgery given as change in glioma size (maximum diameter), survival and adverse events. Follow-up was performed for 36 months. Three dose-groups (<13, 13-14 and >14 Gy) were compared for survival. Results: Mean glioma size decreased from 1.87 cm before RGS irradiation to 1.15 cm at 36 months. Mean survival was 39.5 months. Mean survival after <13, 13-14 and >14 Gy were 22.7, 66.7 and 49 months, respectively (p<0.05). Adverse events, mainly reduced appetite, sleep disturbances, headache and edema, were not associated with RGS dose and were easily managed. Conclusion: RGS radiosurgery led to promising results with acceptable toxicity in patients with low-grade brainstem gliomas. ER -