@article {PHUONG957, author = {PHAM CAM PHUONG and NGUYEN QUANG HUNG and TRAN BAO NGOC and DIRK RADES and MAI TRONG KHOA}, title = {Rotating Gamma System Irradiation: A Promising Treatment for Low-grade Brainstem Gliomas}, volume = {31}, number = {5}, pages = {957--960}, year = {2017}, publisher = {International Institute of Anticancer Research}, abstract = {Aim: To evaluate the role of rotating gamma system (RGS) radiosurgery for low-grade brainstem gliomas. Patients and Methods: Thirty-seven patients undergoing RGS radiosurgery at the Bach Mai Hospital Hanoi for low-grade brainstem glioma were included in this prospective interventional study. The median RGS dose was 12 Gy (range=8-16 Gy). Endpoints included response to RGS radiosurgery given as change in glioma size (maximum diameter), survival and adverse events. Follow-up was performed for 36 months. Three dose-groups (\<13, 13-14 and \>14 Gy) were compared for survival. Results: Mean glioma size decreased from 1.87 cm before RGS irradiation to 1.15 cm at 36 months. Mean survival was 39.5 months. Mean survival after \<13, 13-14 and \>14 Gy were 22.7, 66.7 and 49 months, respectively (p\<0.05). Adverse events, mainly reduced appetite, sleep disturbances, headache and edema, were not associated with RGS dose and were easily managed. Conclusion: RGS radiosurgery led to promising results with acceptable toxicity in patients with low-grade brainstem gliomas.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/31/5/957}, eprint = {https://iv.iiarjournals.org/content/31/5/957.full.pdf}, journal = {In Vivo} }