RT Journal Article SR Electronic T1 SCARB1 Gene Polymorphisms and HDL Subfractions in Coronary Artery Disease JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 873 OP 876 VO 31 IS 5 A1 HUSEYIN AYHAN A1 UZAY GORMUS A1 SELIM ISBIR A1 SEDA GULEC YILMAZ A1 TURGAY ISBIR YR 2017 UL http://iv.iiarjournals.org/content/31/5/873.abstract AB Background/Aim: Cardiovascular diseases are a leading cause of mortality and morbidity worldwide. Polymorphisms in the SCARB1 gene are known to be related to plasma lipids. Patients and Methods: Real time-polymerase chain reaction (RT-PCR) was used for identification of SCARB1 polymorphisms and the Lipoprint Quantimetrix System was employed in identification of HDL subfractions. Results: According to allelic distribution, in both groups SCARB1 AA genotype led to a two-fold decrease in the risk of developing cardiovascular disease (p=0.04), while the GA genotype increased the risk two-fold (p=0.03). According to the HDL subfraction analysis results, the AA genotype had higher levels of big-sized HDL subfraction (p=0.02). Conclusion: The SCARB1AA genotype decreased cardiovascular risk and carrying GA genotype and G allele increased the risk of CAD. AA genotype carriers had higher levels of big-sized HDL subfraction.