RT Journal Article SR Electronic T1 Comparing the Organs and Vasculature of the Head and Neck in Five Murine Species JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 861 OP 871 VO 31 IS 5 A1 MIN JAE KIM A1 YOO YEON KIM A1 JANET REN CHAO A1 HAE SANG PARK A1 JIWON CHANG A1 DAWOON OH A1 JAE JUN LEE A1 TAE CHUN KANG A1 JUN-GYO SUH A1 JUN HO LEE YR 2017 UL http://iv.iiarjournals.org/content/31/5/861.abstract AB Background/Aim: The purpose of the present study was to delineate the cervical and facial vascular and associated anatomy in five murine species, and compare them for optimal use in research studies focused on understanding the pathology and treatment of diseases in humans. Materials and Methods: The specific adult male animals examined were mice (C57BL/6J), rats (F344), mongolian gerbils (Merionesunguiculatus), hamsters (Syrian), and guinea pigs (Hartley). To stain the vasculature and organs, of the face and neck, each animal was systemically perfused using the vital stain, Trypan Blue. Following this step, the detailed anatomy of the head and neck could be easily visualized in all species. Results: Unique morphological characteristics were demonstrated by comparing the five species, including symmetry of the common carotid origin bilaterally in the Mongolian Gerbil, a large submandibular gland in the hamster and an enlarged buccal branch in the Guinea Pig. In reviewing the anatomical details, this staining technique proves superior for direct surgical visualization and identification. Conclusion: The anatomical details provided through these five species atlas will help experimental researchers in the future to select the most appropriate animal model for specific laboratory studies aimed to improve our understanding and treatment of diseases in patients.