TY - JOUR T1 - Osteochondral Repair Using Porous Three-dimensional Nanocomposite Scaffolds in a Rabbit Model JF - In Vivo JO - In Vivo SP - 895 LP - 903 VL - 31 IS - 5 AU - BEATA ŻYLIŃSKA AU - EWA STODOLAK-ZYCH AU - ALEKSANDRA SOBCZYŃSKA-RAK AU - TOMASZ SZPONDER AU - PIOTR SILMANOWICZ AU - MIROSŁAW ŁAŃCUT AU - ŁUKASZ JAROSZ AU - PAWEŁ RÓŻAŃSKI AU - IZABELA POLKOWSKA Y1 - 2017/09/01 UR - http://iv.iiarjournals.org/content/31/5/895.abstract N2 - Aim: To evaluate the utility of a novel nanocomposite biomaterial consisting of poly-L/D-lactide, and hydroxyapatite bioceramics, enriched with sodium alginate in articular cartilage defect treatment. Materials and Methods: The biomaterial was prepared using the method of solvent casting and particle leaching. The study was conducted on 20 New Zealand White rabbits. Experimental osteochondral defects were created in the femoral trochlear grooves and filled with biomaterials. In control groups, the defects were left to spontaneously heal. The quality of newly-formed tissue was evaluated on the basis of macroscopic and histological assessment. Additionally the level of osteogenic and cartilage degradation markers were measured. Results: The majority of the defects from the treatment group were covered with tissue similar in structure and colour to healthy cartilage, whereas in the control group, tissue was uneven, and not integrated into the surrounding cartilage. Conclusion: The results obtained validate the choice of biomaterial used in this study as well as the method of its application ER -