TY - JOUR T1 - Clozapine Associated with Autoimmune Reaction, Fever and Low Level Cardiotoxicity – A Case Report JF - In Vivo JO - In Vivo SP - 141 LP - 143 VL - 31 IS - 1 AU - CHARILAOS GERASIMOU AU - GEORGIA PHAEDRA VITALI AU - GEORGE D. VAVOUGIOS AU - CHARALABOS PAPAGEORGIOU AU - ATHANASIOS DOUZENIS AU - STYLIANI I. KOKORIS AU - IOANNIS LIAPPAS AU - EMMANOUIL RIZOS Y1 - 2017/01/01 UR - http://iv.iiarjournals.org/content/31/1/141.abstract N2 - Background: Clozapine is a second-generation antipsychotic drug used in treatment-resistant schizophrenia. Fever induced by clozapine is a rather frequent side-effect which usually occurs in the first 4 weeks of treatment. Despite its effectiveness, there are potentially life-threatening adverse effects, such as cardiotoxicity. Case Report: We present the case of a 31-year-old caucasian male with refractory schizophrenia who developed benign fever, increase of C-reactive protein and high troponin levels, without presenting any other signs to myocarditis, on the 13th day under clozapine treatment, which declined progressively upon discontinuation of the drug. Discussion: This case hints at the presence of initially subclinical cardiotoxicity as an underlying factor in patients developing fever. Conclusion: Taking advantage of more sensitive methods for measuring troponin, clinicians would be promptly aware of this possible side-effect. This would allow for significant reduction of the risk of cardiac dysfunction, further attained by carefully monitoring the patient. ER -