%0 Journal Article %A CHARILAOS GERASIMOU %A GEORGIA PHAEDRA VITALI %A GEORGE D. VAVOUGIOS %A CHARALABOS PAPAGEORGIOU %A ATHANASIOS DOUZENIS %A STYLIANI I. KOKORIS %A IOANNIS LIAPPAS %A EMMANOUIL RIZOS %T Clozapine Associated with Autoimmune Reaction, Fever and Low Level Cardiotoxicity – A Case Report %D 2017 %J In Vivo %P 141-143 %V 31 %N 1 %X Background: Clozapine is a second-generation antipsychotic drug used in treatment-resistant schizophrenia. Fever induced by clozapine is a rather frequent side-effect which usually occurs in the first 4 weeks of treatment. Despite its effectiveness, there are potentially life-threatening adverse effects, such as cardiotoxicity. Case Report: We present the case of a 31-year-old caucasian male with refractory schizophrenia who developed benign fever, increase of C-reactive protein and high troponin levels, without presenting any other signs to myocarditis, on the 13th day under clozapine treatment, which declined progressively upon discontinuation of the drug. Discussion: This case hints at the presence of initially subclinical cardiotoxicity as an underlying factor in patients developing fever. Conclusion: Taking advantage of more sensitive methods for measuring troponin, clinicians would be promptly aware of this possible side-effect. This would allow for significant reduction of the risk of cardiac dysfunction, further attained by carefully monitoring the patient. %U https://iv.iiarjournals.org/content/invivo/31/1/141.full.pdf