RT Journal Article SR Electronic T1 Definitive Radiation Therapy for Angiosarcoma of the Face and Scalp JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 921 OP 926 VO 30 IS 6 A1 GEN SUZUKI A1 HIDEYA YAMAZAKI A1 HIDEYA TAKENAKA A1 NORIHIRO AIBE A1 KOJI MASUI A1 TAKUYA KIMOTO A1 KOTOHA TATEKAWA A1 AKIHIRO NAKASHIMA A1 TADASHI TAKENAKA A1 JUN ASAI A1 SATOSHI KOMORI A1 MAKOTO WADA A1 NORITO KATOH A1 KEI YAMADA YR 2016 UL http://iv.iiarjournals.org/content/30/6/921.abstract AB Aim: To examine the role of radiation therapy (RT) and factors' influence on tumor control for angiosarcoma of the face and scalp (AS-FS). Patients and Methods: We reviewed the records of 14 patients with histopathology proven AS-FS (median age=77 years) who underwent RT between 2000 and 2015. A total dose of 60 to 100 Gy was administered in 24 to 50 fractions. The median calculated biological effective dose (BED) was 93 Gy (range=63.25-120) based on α/β=10. The median follow-up was 16 months (range=5-62). Results: Of the 14 patients, 8 patients (57%) experienced disease recurrence. The median overall survival (OS) rate was 31 months. The 1-year actuarial OS, event-free survival (EFS) and local control (LC) rates were 83%, 71% and 71%, respectively. In univariate analysis, age ≥78years was a significant prognostic factor for LC and OS. BED ≥95Gy was highly correlated with increased LC with borderline significance (p=0.06). Conclusion: Older patients had significantly lower survival rates and higher local recurrence rates than younger patients. The higher radiation dose may have a potential to improve local control for AS-FS.