RT Journal Article SR Electronic T1 Polymorphism in Murine mtATP8 Gene Correlates with Decreased Reactive Oxygen Species in Aging Hematopoietic Cells JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 751 OP 760 VO 30 IS 6 A1 CATRIN ROOLF A1 CHRISTIN KRETZSCHMAR A1 KATRIN TIMMER A1 ANETT SEKORA A1 GUDRUN KNÜBEL A1 HUGO MURUA ESCOBAR A1 GEORG FUELLEN A1 SALEH M. IBRAHIM A1 MARKUS TIEDGE A1 SIMONE BALTRUSCH A1 SARAH MÜLLER A1 RÜDIGER KÖHLING A1 CHRISTIAN JUNGHANSS YR 2016 UL http://iv.iiarjournals.org/content/30/6/751.abstract AB Background: Mitochondrial DNA (mtDNA) encodes for the respiratory chain proteins. Genetic alterations in mtDNA have been described during aging and linked to impaired hematopoiesis. Materials and Methods: We investigated two novel conplastic mouse strains harboring a mitochondrial nt7778 G/T polymorphism leading to an amino acid exchange in respiratory chain complex V. Effects on reactive oxygen species (ROS) and adenosine triphosphate (ATP) levels, as well as bone marrow composition and peripheral blood counts, were investigated during aging (up to 24 month). Results: The polymorphism correlated with significantly decreased ROS levels in aged mice. Effects on hematopoiesis were marginal and not statistically significant: numbers of erythroid cells in bone marrow, as well as mean corpuscular hemoglobin, tended to decrease over time. Conclusion: The investigated polymorphism is associated with decreased ROS levels in aged hematopoietic cells but does not significantly influence hematopoiesis itself.