RT Journal Article
SR Electronic
T1 Monitoring of L-Arginine and Endogenous Dimethylarginines in Survivor Septic Patients – A Pilot Study
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 663
OP 669
VO 30
IS 5
A1 BALÁZS NÉMETH
A1 ISTVÁN KISS
A1 IVÁN PÉTER
A1 ZÉNÓ AJTAY
A1 ÁDÁM NÉMETH
A1 LÁSZLÓ MÁRK
A1 ATTILA CSORBA
A1 TAMÁS KŐSZEGI
A1 DIÁNA MÜHL
A1 PÉTER KUSTÁN
YR 2016
UL http://iv.iiarjournals.org/content/30/5/663.abstract
AB Background/Aim: Nitric oxide (NO) pathway plays a major role in the development and advancement of inflammation. We aimed to design a study and investigate its feasibility to show the changes of L-arginine, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), which are important regulators of the NO pathway. Patients and Methods: Concentrations of L-arginine, ADMA and SDMA were measured by liquid chromatography-tandem mass spectrometry. Seventeen septic survival patients were enrolled and blood samples were obtained on the first, third and fifth day after the diagnosis of sepsis. Sixteen non-septic matched controls were recruited. Results: ADMA levels on admission correlated well with sequential organ failure assessment (SOFA) score. During the follow-up, L-arginine/ADMA ratio increased significantly from day 1 to day 3 (p=0.005), then decreased from day 3 to day 5 (p=0.023). Conclusion: This study design seems feasible to investigate changes of L-Arginine, ADMA and SDMA in sepsis survival patients.