PT  - JOURNAL ARTICLE
AU  - TAKEDA, SEIICHI
AU  - TODA, TAKAO
AU  - NAKAMURA, KAZUKI
TI  - Inhibitory Effects of Medium Molecular Weight Heparinyl Amino Acid Derivatives on Ischemic Paw Edema in Mice
DP  - 2016 Jul 01
TA  - In Vivo
PG  - 433--437
VI  - 30
IP  - 4
4099  - http://iv.iiarjournals.org/content/30/4/433.short
4100  - http://iv.iiarjournals.org/content/30/4/433.full
SO  - In Vivo2016 Jul 01; 30
AB  - We investigated the radical-scavenging effects of heparin (HE), medium molecular weight heparinyl phenylalanine (MHF), and medium molecular weight heparinyl leucine (MHL) using ischemic paw edema in mice. We also examined the activated partial thromboplastin time (APTT) of mice that were administered these compounds as an index of their side-effects. HE had a preventative effect and significant reduced ischemic paw edema. However, its effect was not dose-dependent and the dose–response curve was bell-shaped. The effective dose of HE also exhibited a prolonged APTT. Pretreatment using MHF and MHL were effective against ischemic paw edema without a prolonged APTT. Remarkably, the action of MHF was not only preventively, but also therapeutically active. These results suggest that MHF and MHL are superior to HE as safe radical scavengers in vivo.