PT  - JOURNAL ARTICLE
AU  - LIESA DZIGGEL
AU  - STEVEN E. SCHILD
AU  - THEO VENINGA
AU  - AMIRA BAJROVIC
AU  - DIRK RADES
TI  - Clinical Factors Associated with Treatment Outcomes Following Whole-brain Irradiation in Patients with Prostate Cancer
DP  - 2017 Jan 01
TA  - In Vivo
PG  - 35--38
VI  - 31
IP  - 1
4099  - http://iv.iiarjournals.org/content/31/1/35.short
4100  - http://iv.iiarjournals.org/content/31/1/35.full
SO  - In Vivo2017 Jan 01; 31
AB  - Background/Aim: Patients with prostate cancer represent a small minority of cancer patients presenting with metastases to the brain. This study investigated the role of whole-brain irradiation (WBI) in this rare group. Patients and Methods: Eighteen such patients were included. Clinical factors including fractionation program of WBI, age at WBI, Karnofsky performance score (KPS), number of metastases to the brain, involvement of extracerebral metastatic sites, time from prostate cancer diagnosis to WBI and recursive-partitioning-analysis (RPA) class were investigated regarding local (intracerebral) control and survival. Results: On multivariate evaluation, longer time from prostate cancer diagnosis to WBI showed a trend towards improved local control (hazard ratio 2.77, p=0.098). Better KPS (hazard ratio 5.64, p=0.021) and longer time from prostate cancer diagnosis to WBI (hazard ratio 5.64, p=0.013) were significantly associated with better survival. Conclusion: Two independent predictors of survival were identified and should be considered when designing for personalized treatment regimens and clinical trials.