RT Journal Article
SR Electronic
T1 Postsurgical Hypoparathyroidism: A Systematic Review
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 171
OP 179
VO 30
IS 3
A1 KASSIANI KAKAVA
A1 SYMEON TOURNIS
A1 GEORGIOS PAPADAKIS
A1 IOANNIS KARELAS
A1 PAVLOS STAMPOULOGLOU
A1 EVANTHIA KASSI
A1 IOANNIS TRIANTAFILLOPOULOS
A1 VASILIKI VILLIOTOU
A1 THEODORE KARATZAS
YR 2016
UL http://iv.iiarjournals.org/content/30/3/171.abstract
AB This article reviews epidemiology, risk factors and treatment modalities of postsurgical hypoparathyroidism (PHypo). PHypo occurs after total thyroidectomy due to injury of parathyroid glands and/or their blood supply or after parathyroidectomy. PHypo results in hypocalcemia because parathyroid hormone (PTH) secretion is impaired and cannot mobilize calcium from bone, reabsorb calcium from the distal nephron and stimulate renal 1α-hydroxylase activity. It usually appears in the first days after surgery and it can be symptomatic or asymptomatic. Risk factors are low level of intraoperative PTH and presence of parathyroid gland in the pathological specimen. Patients usually present with paresthesia, cramps or tetany, but the disorder may also manifest acutely with seizures, bronchospasm, laryngospasm or cardiac rhythm disturbances. Standard treatment is vitamin D analogues and calcium supplementation.