TY - JOUR T1 - Solid Organ Cool-tip Radiofrequency Ablation: An Experimental Study with Clinicopathological Correlations JF - In Vivo JO - In Vivo SP - 41 LP - 45 VL - 30 IS - 1 AU - MICHALIS KONTOS AU - ELIAS DRAKOS AU - APOSTOLOS PAPALOIS AU - ATHANASIOS PETROU AU - EMMANOUIL PIKOULIS AU - EVANGELOS FELEKOURAS Y1 - 2016/01/01 UR - http://iv.iiarjournals.org/content/30/1/41.abstract N2 - Background/Aim: Radiofrequency ablation (RFA) with internally cooled electrodes is a technique for the in situ treatment of solid tumors, inducing characteristic pathological changes with limited clinical complications. Our purpose was to assess RFA-induced histological alterations and correlate them with clinical complications. Materials and Methods: Using a porcine model, the pathology of RFA-induced kidney, liver and spleen lesions was associated with the postoperative course and clinical complications recorded. Results: Complications and relevant histological lesions, including abscess formation, hemorrhage and bile or urinary leakage, were limited or absent. The majority of RFA-induced necrotic tissue exhibited preserved architecture, with relatively limited inflammatory reaction, associated with sealing of blood/bile vessels or urinary tubules along the periphery of the lesions. Conclusion: The preserved architecture of RFA-induced necrotic tissue, its slow clearance, the relatively limited inflammation and the ability of RFA to seal blood/bile/urinary vessels are probably responsible for the minimal complications observed. ER -