PT  - JOURNAL ARTICLE
AU  - MICHALIS KONTOS
AU  - ELIAS DRAKOS
AU  - APOSTOLOS PAPALOIS
AU  - ATHANASIOS PETROU
AU  - EMMANOUIL PIKOULIS
AU  - EVANGELOS FELEKOURAS
TI  - Solid Organ Cool-tip Radiofrequency Ablation: An Experimental Study with Clinicopathological Correlations
DP  - 2016 Jan 01
TA  - In Vivo
PG  - 41--45
VI  - 30
IP  - 1
4099  - http://iv.iiarjournals.org/content/30/1/41.short
4100  - http://iv.iiarjournals.org/content/30/1/41.full
SO  - In Vivo2016 Jan 01; 30
AB  - Background/Aim: Radiofrequency ablation (RFA) with internally cooled electrodes is a technique for the in situ treatment of solid tumors, inducing characteristic pathological changes with limited clinical complications. Our purpose was to assess RFA-induced histological alterations and correlate them with clinical complications. Materials and Methods: Using a porcine model, the pathology of RFA-induced kidney, liver and spleen lesions was associated with the postoperative course and clinical complications recorded. Results: Complications and relevant histological lesions, including abscess formation, hemorrhage and bile or urinary leakage, were limited or absent. The majority of RFA-induced necrotic tissue exhibited preserved architecture, with relatively limited inflammatory reaction, associated with sealing of blood/bile vessels or urinary tubules along the periphery of the lesions. Conclusion: The preserved architecture of RFA-induced necrotic tissue, its slow clearance, the relatively limited inflammation and the ability of RFA to seal blood/bile/urinary vessels are probably responsible for the minimal complications observed.