RT Journal Article
SR Electronic
T1 Prevalence and Risk Factors for Significant Liver Fibrosis in Patients with HIV Infection
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 771
OP 775
VO 29
IS 6
A1 MAGGI, PAOLO
A1 ALTIZIO, SERGIO
A1 DI BIAGIO, ANTONIO
A1 NICOLINI, LAURA
A1 VOLPE, ANNA
A1 TANCORRE, TIZIANA
A1 LEONE, ARMANDO
A1 BELLACOSA, CHIARA
A1 LADISA, NICOLETTA
A1 ANGARANO, GIOACCHINO
YR 2015
UL http://iv.iiarjournals.org/content/29/6/771.abstract
AB Aim: The aim of the present study was the evaluation of liver fibrosis in a population of patients monoinfected with HIV using the transient liver elastography (FibroScan) method. Patients and Methods: A total of 228 consecutive patients with HIV were evaluated: 80 (35.09%) were HIV-1 monoinfected and 148 (64.91%) (HIV)/hepatitis C virus (HCV) co-infected. Echoic liver diagnosis was also performed. Results: F2 Metavir-score fibrosis or higher was found to be associated with drug addiction, alanine aminotransferase >80 UI/l, cluster of differentiation 4 (CD4+) T lymphocytes nadir <200 copies/ml, therapy duration, protease inhibitor (PI)-based antiretroviral regimen, HCV infection and AIDS diagnosis. Multivariate analysis highlighted a significant association with drug addiction, AIDS diagnosis, therapy duration and HCV co-infection. Echoic liver diagnosis showed signs of damage among 43.75% of monoinfected patients vs. 62.84% among co-infected. Conclusion: Monoinfected patients showed pathological signs both at liver ultrasonography and at FibroScan. In the onset of these changes, a significant role by HIV disease and duration of therapy is observed.