PT  - JOURNAL ARTICLE
AU  - MAGGI, PAOLO
AU  - ALTIZIO, SERGIO
AU  - DI BIAGIO, ANTONIO
AU  - NICOLINI, LAURA
AU  - VOLPE, ANNA
AU  - TANCORRE, TIZIANA
AU  - LEONE, ARMANDO
AU  - BELLACOSA, CHIARA
AU  - LADISA, NICOLETTA
AU  - ANGARANO, GIOACCHINO
TI  - Prevalence and Risk Factors for Significant Liver Fibrosis in Patients with HIV Infection
DP  - 2015 Nov 01
TA  - In Vivo
PG  - 771--775
VI  - 29
IP  - 6
4099  - http://iv.iiarjournals.org/content/29/6/771.short
4100  - http://iv.iiarjournals.org/content/29/6/771.full
SO  - In Vivo2015 Nov 01; 29
AB  - Aim: The aim of the present study was the evaluation of liver fibrosis in a population of patients monoinfected with HIV using the transient liver elastography (FibroScan) method. Patients and Methods: A total of 228 consecutive patients with HIV were evaluated: 80 (35.09%) were HIV-1 monoinfected and 148 (64.91%) (HIV)/hepatitis C virus (HCV) co-infected. Echoic liver diagnosis was also performed. Results: F2 Metavir-score fibrosis or higher was found to be associated with drug addiction, alanine aminotransferase >80 UI/l, cluster of differentiation 4 (CD4+) T lymphocytes nadir <200 copies/ml, therapy duration, protease inhibitor (PI)-based antiretroviral regimen, HCV infection and AIDS diagnosis. Multivariate analysis highlighted a significant association with drug addiction, AIDS diagnosis, therapy duration and HCV co-infection. Echoic liver diagnosis showed signs of damage among 43.75% of monoinfected patients vs. 62.84% among co-infected. Conclusion: Monoinfected patients showed pathological signs both at liver ultrasonography and at FibroScan. In the onset of these changes, a significant role by HIV disease and duration of therapy is observed.