@article {GKIOKA637, author = {ELIONA GKIOKA and PAVLOS MSAOUEL and ANASTASSIOS PHILIPPOU and NIKOLAOS I. VLACHOGIANNIS and CHRISTIANA T. VOGKOU and ARGYRIS MARGIOLIS and MICHAEL KOUTSILIERIS}, title = {The Role of Insulin-like Growth Factor-1 Signaling Pathways in Uterine Leiomyoma}, volume = {29}, number = {6}, pages = {637--649}, year = {2015}, publisher = {International Institute of Anticancer Research}, abstract = {A growing body of evidence suggests the association of the IGF-I bio-regulatory system with leiomyoma occurrence and growth. The complex interplay between IGF-I/IGF-IR and hormonal and other growth factors is, thus, now receiving significant attention. Elucidation of the molecular mechanisms driving the disease may allow for development of novel targeted-therapeutic strategies for the treatment of leiomyomas. Herein, we provide a concise update and overview of the function and regulation of IGF-I and its role in leiomyoma growth.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/29/6/637}, eprint = {https://iv.iiarjournals.org/content/29/6/637.full.pdf}, journal = {In Vivo} }