RT Journal Article
SR Electronic
T1 Does Serum Lactate Combined with Soluble Endothelial Selectins at ICU Admission Predict Sepsis Development?
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 305
OP 308
VO 29
IS 2
A1 ALICE G. VASSILIOU
A1 ZAFEIRIA MASTORA
A1 EDISON JAHAJ
A1 ANTONIA KOUTSOUKOU
A1 STYLIANOS E. ORFANOS
A1 ANASTASIA KOTANIDOU
YR 2015
UL http://iv.iiarjournals.org/content/29/2/305.abstract
AB Aim: We sought to determine for serum lactate its specificity and sensitivity in sepsis development prognosis in critically-ill, non-septic patients. Additionally, we evaluated whether sE-selectin or sP-selectin add prognostic value to lactate in sepsis. Patients and Methods: Using a cohort previously studied in another context, in this retrospective investigation we plotted receiver operating characteristic (ROC) curves using sepsis development as the classification variable and serum lactate levels and their linear combinations with soluble sE-selectin and/or sP-selectin levels at intensive care unit (ICU) admission, as prognostic variables. Results: Lactate levels combined with sE- and sP-selectin levels have the best prognostic accuracy showing a sensitivity and specificity of 76% and 84%, respectively, and an area under the curve (AUC) at 0.854 (95% confidence interval (CI)=0.775-0.932; p<0.001). Conclusion: In our patient cohort, combining sE- and sP-selectin with serum lactate offers better prognostic value for sepsis development during ICU hospitalization.