TY - JOUR T1 - Small Leucine Rich Proteoglycans Are Differently Distributed in Normal and Pathological Endometrium JF - In Vivo JO - In Vivo SP - 217 LP - 222 VL - 29 IS - 2 AU - ANGELA LUCARIELLO AU - ELISABETTA TRABUCCO AU - OLGA BOCCIA AU - ANGELICA PERNA AU - CARMINE SELLITTO AU - MARIA A. CASTALDI AU - MARIA DE FALCO AU - ANTONIO DE LUCA AU - LUIGI COBELLIS Y1 - 2015/03/01 UR - http://iv.iiarjournals.org/content/29/2/217.abstract N2 - Background: During the woman's fertile period, the non-pregnant uterus is subject to constant cyclic changes. The complex mechanisms that control the balance among proliferation, differentiation, cell death and the structural remodeling of the extracellular matrix can contribute to the benign or malignant endometrial pathological state. The small leucine-rich proteoglycans (SLRPs) are important components of cell surface and extracellular matrices. Materials and Methods: Using immunohistochemistry, we showed that the distribution patterns of SLRPs were completely modified in the pathological compared to normal endometrium. Results: The expression of SLRPs was low/absent in all endometrial pathologies examined compared to normal endometrium. We observed an increase of lumican from proliferative to secretory phase of the endometrium and a decrease of fibromodulin, biglycan and decorin. In menopause endometrial tissue, the level of expression of fibromodulin, biglycan, decorin and lumican dramatically decreased. Conclusion: The results revealed the prominence and importance of proteoglycans in the tissue architecture and extracellular matrix organization. ER -